Variability in patient’s response to drugs treatment represents a major challenge to doctors as one drug doesn’t suit all. This variability occurs as a result of differential genetic traits that are present in an individual. Each person has uniqueness in how his body interacts with administered drugs. In some individuals it may lead to significant drug toxicities and/ or risk of drug efficacy which becomes even more important when drugs are prescribed for longer time duration.

The majority of known adverse drug reactions (ADRs), 60% approximately, are triggered via exposure to drugs that are metabolized by liver enzymes with altered functions; induced by genetic mutations. Implementation of PGX testing has the potential to prevent occurrence of serious drugs related events; in some case leading to death.